5/20/2023 0 Comments 2054 by Alexandre Delong![]() ![]() Thus, CoQ 10 supplementation may ameliorate the age-related decline in motor function in humans. These data suggest that CoQ 10 restores the motor function of middle-aged mice by improving brain mitochondrial function and the basal fEPSP level of the motor cortex, potentially by enhancing synaptic plasticity efficacy. Importantly, the fEPSP amplitude showed a larger input‒output relationship after CoQ 10-dependent LTP expression. Interestingly, CoQ 10 with high-frequency stimulation induced NMDA receptor-dependent long-term potentiation (LTP) in layer V of the primary motor cortex of middle-aged mice. ![]() Notably, we identified an age-related decline in field excitatory postsynaptic potential (fEPSP) amplitude in the pathway from layers II/III to V of the primary motor area of middle-aged mice, which was restored to the young adult level by supplementing with CoQ 10 for 1 week but not by administering CoQ 10 acutely to brain slices. CoQ 10 supplementation concurrently improved brain mitochondrial respiration but not muscle strength. ![]() We confirmed that middle-aged mice at 15–18 months old show motor function decline, which can be restored to the young adult level by supplementing with mitochondrial electron transporter coenzyme Q 10 (CoQ 10) as a water-soluble nanoformula by drinking water for 1 week. Physiological aging causes motor function decline and anatomical and biochemical changes in the motor cortex. ![]()
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